What is the difference between Polynucleotides (Rejuran ®) vs Hyaluronic acid explained by Dr. Avaliani

Why do we need peptides and polynucleotides?

You can’t just keep collecting the fruits and harvest without planting seeds, watering the soil and adding boosters such a fertilizers. The skin can withstand so many laser treatments before it just doesn’t respond the same way and we need to nourish it in a way farmer nurtures the soil when planting the seeds to enjoy the fruits of labor during the harvest season.

“Think of Polynucleotides as a fertilizer for the soil to ensure a great harvest with good nutrients”

Rejuran ® is a skin rejuvenation treatment that is made out of polynucleotides, which are biopolymers derived from salmon DNA. These polynucleotides help to promote:

• skin regeneration
• improve hydration
• enhance overall skin texture and elasticity
• stimulate collagen production
• and accelerate tissue healing
• helps calm down inflammation in acne and rosacea

Dermal fillers from Hyaluronic acid like Juvederm® and Restylane® offer the following qualities and are making it popular for addressing signs of aging and improving skin appearance with immediate gratification

• Immediate Volume and Contour
• Wrinkle Reduction
• Skin Hydration
• Customizable Results
• Long-lasting Effects
• Minimal Downtime

Polynucleotides and hyaluronic acid are both popular components in skin rejuvenation, but they serve different purposes. Polynucleotides, derived from salmon sperm DNA, primarily focus on stimulating collagen production, enhancing cellular regeneration, and improving skin healing. They are known for their regenerative properties, helping to rejuvenate the skin by promoting tissue repair and reducing inflammation. In contrast, hyaluronic acid is a naturally occurring substance in the body that primarily acts as a powerful hydrator, attracting and retaining moisture in the skin. This makes it excellent for hydration and plumping, addressing dryness and fine lines. Both products contribute to healthier skin but polynucleotides emphasize regeneration and repair, whereas hyaluronic acid focuses on hydration and maintaining skin volume.

Rejuran ® focuses on skin health and regeneration, improving texture and elasticity over time, while dermal fillers provide immediate volume and contour.

Can you combine polynucleotides and dermal fillers in the same setting?

The choice between Rejuran ® and dermal fillers depends on individual goals: whether you seek overall skin rejuvenation or immediate volume enhancement. Many people choose combination of both to achieve comprehensive skin rejuvenation during the same treatment to decrease the number of sessions needed and also possible recovery time or any bruising that can be associated with the injection.

How are Polynucleotides administered?

Polynuclotide treatments are known for being biocompatible and safe for most skin types. They can be administered through injections or applied topically after a treatments like microneedling, Laser microneedling with RF, laser microcoring, fractional non ablative lasers and fractional ablative laser treatments.

What is Rejuran® ?

Rejuran® is a skin rejuvenation treatment that uses polynucleotides, which are biopolymers derived from salmon DNA. These polynucleotides help to promote skin regeneration, improve hydration, and enhance overall skin texture and elasticity. The treatment aims to stimulate collagen production and accelerate healing, making it popular for addressing signs of aging and improving skin appearance. It\’s typically administered through injections and is known for being biocompatible and safe for most skin types.

Does Rejuran® Offer Skin Regeneration?

Rejuran® is designed to stimulate collagen and elastin production, promoting overall skin rejuvenation. This results in improved skin texture, elasticity, and firmness over time

Does Rejuran® Offer Skin Hydration?

Rejuran® enhances skin hydration by promoting moisture retention, leading to a plumper and more youthful appearance. It does not add volume like HA fillers.

Does Rejuran® Offer Healing and Repair properties?

The regenerative properties of polynucleotides accelerate the healing process of damaged skin, making it beneficial for post-acne scars, sun damage, scars, burns and other skin imperfections.

Does Rejuran® Offer Anti-Inflammatory Effects?

Rejuran® has soothing properties that can help reduce inflammation and redness, making it suitable for sensitive skin or conditions like rosacea.

What is Rejuran’s ® Biocompatibility and Safety profile?

Being derived from salmon DNA, Rejuran is highly biocompatible, minimizing the risk of allergic reactions and making it safe for various skin types.

Here’s a detailed comparison of the benefits of Rejuran (polynucleotide treatment) versus HA (Hyaluronic acid ) dermal fillers:

Properties	Rejuran ®	HA fillers (Juvederm®/Restylane ®
Skin regeneration	Yes	No
Skin hydration	Yes	Yes
Improved elasticity	Yes	No
Anti inflammatory	Yes	No
Healing and repair	Yes	No
Wrinkle reduction	Yes	Yes
Acne scars	Yes	Yes
Biocompatibility	Yes	Yes
Volumization ability	No	Yes
Contouring ability	No	Yes
Body areas of use	Full body	Select areas on face and body
Method of delivery	Laser and needle	Laser and needle
Duration of effect	Months -years	Months-years
Number of sessions	1-3 varies	1-3 varies
Downtime	24 hrs	24 hrs
Customizable results	Yes	Yes
Results	Takes time	Immediate and instant results

How to determine which one is best for you?

Schedule your in person consultation with skin expert, Dr.Avaliani to find out the best option for your skin needs and start investing in your skin now, please call/text 212-673-8888 or email to: hello@dravaliani.com