Rejuran PDRN Skin Treatment
Salmon DNA Polynucleotide Therapy for Deep Skin Regeneration & Rejuvenation
Expertise
Injector in US
Experience
12k + Patients
Excellence
25+ Injectables
Why Choose Dr. Avaliani for Rejuran PDRN?
Rejuran PDRN represents a breakthrough in skin regeneration technology, using polydeoxyribonucleotides (PDRN) derived from salmon DNA — which shares 97% similarity with human DNA. This innovative treatment promotes collagen production, stimulates fibroblast activity, and supports natural cell regeneration at the deepest level. The result is visibly healthier, more hydrated, and more youthful skin from the inside out.
DNA-Based Science
PDRN technology uses greater than 95% pure DNA fragments from wild salmon reproductive cells, processed with DOT™ (DNA Fragments Optimizing Technology) for maximum biocompatibility and cellular regeneration
Board-Certified Physician
11+ years of aesthetic medicine experience — Dr. Avaliani was among the first providers in NYC to offer Rejuran PDRN and personally administers every treatment
Minimal Downtime
Minimal downtime — redness and dryness typically resolve within 2 hours, with most patients returning to normal activities the same day
A Reputation Built on Results
5.0-star rating with 565+ verified patient reviews and proven skin rejuvenation outcomes with visibly healthier, more luminous skin
Personalized Approach
Customized treatment plans using the right Rejuran formulation and delivery method for your specific skin concerns and goals
What Is Rejuran PDRN?
PDRN stands for PolyDeoxyRiboNucleotides — a DNA structure component derived from salmon DNA that shares 97% similarity with human DNA. Rejuran products use wild Korean salmon reproductive cells processed with PharmaResearch’s DOT™ technology for greater than 95% purity. When delivered into the skin, PDRN promotes collagen production, stimulates fibroblast activity, and supports natural cell regeneration for deep, lasting skin improvement.
At Dr. Avaliani’s practice, Rejuran PDRN is delivered using advanced techniques for maximum penetration and effectiveness. The treatment is often combined with microneedling or fractional laser technologies like Genius RF, ICON, or PicoSure Focus to enhance product absorption deep into the dermal layer. This combination approach accelerates recovery 50–70% faster than laser alone while delivering superior skin regeneration results.
How Rejuran PDRN Works
Rejuran PDRN therapy follows a science-based protocol:
Dr. Avaliani evaluates your skin quality and selects the optimal Rejuran formulation for your concerns
PDRN polynucleotides are delivered into the skin via microneedling or laser-assisted absorption
The DNA fragments activate fibroblasts and stimulate natural collagen and elastin production at the cellular level
Skin regeneration occurs from within as new collagen forms, hydration improves, and damaged cells are repaired
Over a series of treatments spaced 2–4 weeks apart, skin becomes progressively brighter, smoother, and more resilient
Conditions We Treat with Rejuran
Fine Lines & Wrinkles
Crow’s feet, forehead lines, and fine wrinkles across the face. PDRN stimulates collagen and elastin production at the cellular level, gradually smoothing fine lines and restoring the skin’s natural elasticity and firmness from within.
Under-Eye Rejuvenation
Dark circles, thin skin, and crepiness under the eyes. Rejuran’s regenerative properties improve skin thickness, texture, and hydration in the delicate periorbital area, reducing the appearance of hollows and darkness without filler.
Dull & Dehydrated Skin
Skin that has lost its natural glow and appears dry, lackluster, or tired. PDRN deeply rehydrates the skin and promotes fibroblast activity, restoring the luminous, healthy complexion that comes from genuine cellular regeneration rather than surface-level hydration.
Acne Scars & Skin Texture
Uneven skin texture, enlarged pores, and post-acne scarring. When combined with microneedling or fractional lasers, Rejuran PDRN enhances the skin’s healing response, accelerating collagen remodeling for smoother, more refined skin texture.
Hyperpigmentation
Sun spots, melasma, and uneven skin tone. The Rejuran Tone-Up Booster combines PDRN with tranexamic acid, glutathione, and vitamin C to brighten darkened areas and reduce hyperpigmentation while simultaneously regenerating the skin.
Post-Laser Recovery
Accelerated healing after laser skin resurfacing, microneedling, or chemical peels. PDRN’s anti-inflammatory properties speed up post-procedure recovery by 50–70%, reducing redness and downtime while enhancing the regenerative results of the primary treatment.
Our Rejuran Products
Three specialized Rejuran formulations for targeted skin regeneration:
Call us today to schedule your Rejuran PDRN consultation with Dr. Avaliani and discover the future of skin regeneration!
Does It Hurt?
Your Comfort Options (We Tailor This to You)
Rejuran PDRN treatment is comfortable and well tolerated. When delivered via microneedling, topical numbing cream is applied beforehand. When combined with laser treatments, the PDRN actually accelerates healing and reduces discomfort. Most patients describe the experience as very manageable, and Pro-Nox (nitrous oxide) is available for additional comfort.
Downtime is minimal. Redness and mild dryness typically resolve within 2 hours. When combined with laser procedures, PDRN’s anti-inflammatory properties speed recovery by 50–70% compared to laser alone. Dr. Avaliani recommends waiting 24 hours before applying makeup and avoiding strenuous exercise for the first day.
Feel Calm. Stay in Control. Look Amazing.
✓
Reduced Anxiety
Settle into a calm, relaxed state before and during your treatment — no stress, no tension.
✓
Less Discomfort
Enhanced comfort for your treatment, so you can focus on your results.
✓
No Downtime
Walk out feeling great and drive yourself home — absolutely no recovery time required.
PRO-NOX™
Nitrous Oxide
Available On Request
For patients who prefer an extra layer of relaxation, Pro‑Nox™ provides a gentle, calming effect that wears off instantly. Most patients find their treatments very manageable — but it’s always here if you want it.
View Before &
After Gallery
Is Rejuran PDRN Right for Me?
Ideal Candidates
You may be a good candidate if you:
Want to improve overall skin quality, hydration, and luminosity from within
Have fine lines, wrinkles, or loss of skin elasticity
Have dark circles or thin skin under the eyes
Have hyperpigmentation, sun damage, or uneven skin tone
Want to enhance recovery after laser or microneedling treatments
Are looking for a science-based approach to deep skin regeneration
What Does Rejuran PDRN Cost?
Pricing Information
The cost of Rejuran PDRN therapy depends on the product type selected, the treatment area, and the number of sessions in your protocol.
Price Range:
Treatments are typically spaced 2–4 weeks apart, with maintenance every 3 to 12 months depending on skin quality
During your consultation, Dr. Avaliani will evaluate your skin, discuss your goals, and recommend the optimal Rejuran formulation and delivery method with transparent pricing. A series of treatments delivers the best results, with progressive improvement in skin quality after each session.
Individual results may vary. No guarantee of specific results can be given. The degree of side effects and duration of results may vary. Content is for informational
purposes and does not substitute for professional medical advice provided during an in-office consultation and examination by a physician.
Luxury Treatments.
Flexible Payment Options.
Your Confidence Should Never Have to Wait.
At Anna Avaliani MD Cosmetic & Laser Surgery, we believe exceptional aesthetic care should be accessible when you are ready — not months or years later. That’s why we offer elegant financing solutions that allow you to begin your transformation today while comfortably managing the investment over time. Because confidence is priceless — and now it’s flexible.